Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Acta Academiae Medicinae Sinicae》 2005-06
Add to Favorite Get Latest Update

Effect of Coeloglossum. viride var. bracteatum Extract on Oxidation Injury in Sub-acute Senescent Model Mice

Zhang Dan, Zhang Jian-jun# (Department of Pharmacology, Institute of Materia Medica, CAMS and PUMC, Beijing 100050, China)  
Objective To study the anti-aging effects of Coeloglossum. viride(L) Hartm. var. bracteatum(Willd)Richter extract(CE)on senescent model mice induced by D-galactose and sodium nitrite. Methods After one week of accommodation, 60 female NIH mice were divided into six groups with 10 mice in each group: normal control group, aging model group, Piracetam (positive control) group[300 mg/(kg·d)], and CE reatment groups?眼2.5, 5, and 10 mg/(kg·d)]. Mice in aging model group, Piracetam group, and CE treatment group were consecutively intraperitoneally injected with D-galactose[120 mg/(kg·d)]and sodium nitrite[90 mg/(kg·d)]for 60 days. From day 47, mice in Piracetam group and CE treatment group were po given Piracetam 300 mg/(kg·d) or CE 2.5, 5, and 10 mg/(kg·d). Mice in normal control group and aging model group were po given saline. The drug administration lasted for 14 days. Water maze test was performed to evaluate the learning and memory function in the mice. The activity of superoxide dismutase(SOD), the content of malondialdehyde(MDA), and the activities of adenosinetriphosphatase(ATPase), and monoamine-oxidase(MAO)in brain tissue were measured. Results The latencies in water maze test in aging model group mice were significantly longer than in normal control group(P 0.01,P 0.05), and the number of errors increased(P 0.05). In aging model group mice, the activities of SOD,Na+K+-ATPase, and Ca2+Mg2+-ATPase decreased(P 0.01,P 0.05), while the content of MDA and the activities of MAO-A and MAO-B increased(P 0.01). Piracetam[300 mg/(kg·d), po]and CE[2.5, 5, 10 mg/(kg·d), po]ameliorated the above changes in aging model mice. Conclusion CE may improve the memory dysfunction induced by consecutive injection of D-galactose and sodium nitrite, and has nootropic and antiaging effects.
【CateGory Index】: R29
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 QIN Xiao-yan,LI Rong-chang,YUN Miao-ying,TANG Li,YAN Li,DAI Jin-feng(College of Life & Environmental Science,Central University for Nationalities,Beijing,100081);Effect of Tibetan medicine Wangla water-decoction on the immunological function of mice[J];Shandong Journal of Traditional Chinese Medicine;2007-12
2 QIN Xiao-yan,YUN Miao-ying,TANG Li,YAN Li,DAI Jing-feng(College of Life and Environmental Sciences,Central University for Nationalities,Beijing 100081,china);Progress in the Research on Chemical Constituents and Pharmacological Activities of Coeloglossum[J];Journal of the Central University for Nationalities(Natural Sciences Edition);2007-03
【Citations】
Chinese Journal Full-text Database 2 Hits
1 BX Wang and XG Chen (Department of Pharmacology, Academy of Traditional Chinese Medicine and Materia Medica of Jilin Province,Changchun 130021);INHIBITORY EFFECT OF HYPOXANTHINE ON MONOAMINE OXIDASE ACTIVITY[J];Acta Pharmaceutica Sinica;1989-08
2 LUO Huan min,CHEN Zi sheng(Department of Pharmacology, College of Pharmacy, Jinan University, Guangdong Guangzhou 510632);A novel animal model of Alzheimer's disease[J];Chinese Journal of Gerontology;2003-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Jin Yi Institute of Preclinical Science,Norman Bethune University of Medical Sciences;EFFECT OF SELENIUM AND VITAMIN E ON MONO AMINES AND MONOAMINE OXIDASE[J];Chinese Journal of Control of Endemic Disease;1997-02
2 Zhou Haiou~*, You Gengye, Chert Xiaoguang, Liu Shiyue, Wang Benxiang(Institute of Traditional Chinese Medicine and Materia Medica of Jilin Province, Changchun 130021);Analysis on Hydrolysates(Hypoxanthine and Adenine) in Alkaline Solution of Monoamine Oxidase From Liver Tissues of Mice by Reversed-phase Liguid Chromatography[J];Chinese Journal of Analytical Chemistry;1992-04
3 LI Ting~1,LIU Jian-wen~(1),CAO Yan~1,ZHANG Xiao-dong~1,WEI Dong-zhi~2,LU Yan-hua~2(1.School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China;2.State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology);Neuroprotective Effect of Picrosides on Analog Dementia Model in Mice Induced by Galactose and Nitrite Natrium[J];Journal of East China University of Science and Technology(Natural Science Edition);2006-05
4 Li Jinglun, Xu Xiaowu,Liu Changzheng.Department of Neurology,the first affiliated hospital of Luzhou Medical College,Sichun 646000;Study of hoperbarlc oxygen combined with estradlol therapy on learning and memoryy disfunction in senile dementia rats[J];Henan Journal of Practical Neurons Diseases;2005-03
5 Hu Mei,Liu Qunliang,Zhang Yuejuan,et al(TCM Univ.of Hunan,Changsha,410007);Experimental Study on Effect of Huan Shao Dan on Monoamine Oxidase Activity in Rats[J];Journal of Hunan Traditional Chinese Medicine University of Hunan;2005-05
6 YANG Fan,ZHANG Hong,XU Jing(Geriatrics Department of Affiliated Gulou Hospital,Nanjing University of Chinese Medicine,Nanjing,Jiangsu,210008,China);Effect of Prescriptions for Reinforcing Kidney and Invigorating Spleen on Memory of Dementia Rat Model Induced by Ibotenic Acid[J];Journal of Nanjing University of Traditional Chinese Medicine;2008-06
7 XIE Ning, SONG Lin-li, NIU Ying-cai, WANG Miao, JI Ren-jun, DAI Xiao-guang (Heilongjiang University of Chinese Medicine, Harbin 150040, China);Advances and Evaluation on Research of Animal Models of Alzheimer's Disease[J];Laboratory Animal and Comparative Medicine;2006-01
8 Chen,Xiao-guang Wang,Ben-xiang Zhang,Jie Zhang,Hong(Department of Pharmacology,Academy of Traditional Chinese Medicine and Maleria Medica of Jilin Province,Changchun 130021);Inhibitory Effect Of Uracil On Monoamine Oxidase Activity[J];;1992-01
9 DING Xiao_juan, HU Feng_lin, FAN Mei_zhen, LI Zeng_zhi ulture University , Hefei 230036,China);Study on monoamine oxidawe inhibition of extracts from eight strains of Beauveria sp[J];Journal of Biology;2004-03
10 CAO Rong- feng1, CUI Li- chun2, MA Ze- fang1 (1.Faculty of Animal Science and Veterinary Medicine , Qingdao Agricultural University, Qingdao266109,China; 2. College of Wildlife Resources, Northeast Forestry University, Harbin 150040,China);HPLC Analysis of the Uracil and Hypoxanthine Contents in Blood Taken From the Male Sika Deer in Different Rearing Periods.[J];Special Wild Economic Animal and Plant Research;2009-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 HAN Guang-Xuan 1, WANG Li-Xin 2, ZHANG Wei-Dong 2, WANG Mai-Li 1, LIU Hong-Tao 1, XIAO Jian-Hua 1(1. No.534 Hospital of PLA, Luoyang 471003, China; 2. Department of Natural Pharmaceutical Chemistry, College of Pharmacy,Second Military Medical Univer;Studies on chemical constituents of Bletilla striata Ⅱ[J];Academic Journal of Second Military Medical University;2002-09
2 Gao lin~(1,2),Zhang boai~(1) Chen lieran~1,et al.1.Department of Neurology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou,450052 2.The medical college of Henan Universify;Study the change of choline acetyltransferase and acetylcholinesterase activity in normal different age rat[J];Chinese Journal of Practical Neruous Diseases;2006-02
3 XIE Jing, ZHANG Hao*, YU Sen, CHEN Chu (West China School of Pharmacy, Sichuan University, Chengdu 610041, China);Pharmacognostic identification of original plants of Tibetan medicine “Shoushen”[J];West China Journal of Pharmaceutical Sciences;2005-03
4 ZHANG Shi yi, CHEN Yan, ZUO Ping ping, et al (Institute of Basic Medical Sciences, CAMS & PUMC, Beijing 100005, China);Therapeutic effect of 764-3 on rat with Alzheimer's like disease[J];Basic Medical Sciences and Clinics;2001-01
5 WU Shu-liang,JIN Lian-hong,LI Hu-lun,SONG Tie-jun, TIAN B o, YAN Bin-bin (Neurobiology Department of Harbin Medical University, HeilongjiangHarbin150086 China);The Effect of Gingkgo Biloba Leaf on Alzheimer Disease ( AD)[J];Progress of Anatomical Sciences;2004-04
6 Liu Huiling, Duan Xiaoli, Li Zhuyi, Wang Bairen, Ju Gong (The Institute of Neuroscience PLA, Fourth Military Medical University, Xi'an 710032);INFLUENCE OF THE CONCENTRATION OF FIXATIVE AND THE TIME OF FIXATION ON THE IMMUNOHISTOCHEMICAL REACTION BETWEEN THE ANTIBODY AGAINST HUMAN AchR AND RAT nAchR[J];Chinese Journal of Anatomy;2000-06
7 LU Cheng, HU Xiao-ling, ZHU Gao-chun, WANG Wei, SHI Jia-qing (Department of Anatomy,Jiangxi Medical College,Nanchang 330006,China);Establishment of A Rat Model with Alzheimer's Disease Induced by Beta-amyloid Protein[J];Acta Academiae Medicinae Jiangxi;2005-01
8 YE Jin, LIU Xie-He,DENG Hong, et al. Department of Neurology, Xuan Wu Hospital, Capital University of Medical Science, Beijing 100053, China;Experimental Observation on Neuronal Apoptosis Induced by β-amyloid Peptide and Its Mechanism of Oxidative Stress[J];Chinese Journal of Clinical Neurosciences;2002-04
9 LI Long-xuan,RU Li-qiang,YIN Guang-fu,et al (Department of Neurology,the affliatted Hospital of Guangdong Medical College,Zhanjiang 524000,China);Mechanism of tanshinone in treatment of rat with Alzheimer's disease[J];Editorial Department of Chinese Journal of Geriatric Cardiovascular and Cerebrovascular Disease;2003-05
10 HUANG Sheng-yang,et al (Institute of Materia Medica,Chinese Academy of Medical Science);The Analysis of Amino Acid in Tibetan Medicine Wangla [Rhizoma [JZ]of Coeloglossum Viride(L.) Harm.Var.bracteatum(Willd.)Richter][J];Chinese Journal of Ethnomedicine and Ethnopharmacy;2002-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved