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Content Determination of Favipiravir Tablets by HPLC

Liu Cuiyan;Zhang Yuanyuan;Bu Lichao;Liu Yongjin;Liu Lei;CSPC Zhongqi Pharmaceutical Technology(Shijiazhuang) Co.,Ltd.;  
Objective:To establish an HPLC method to determine the content of self-made favipiravir tablets.Methods:The chromatographic column was a CAPCELL PAK MGⅡC18(250 mm × 4.6 mm,5 μm) column,the mobile phase was 0.01 mol·L-1ammonium dihydrogen phosphate solution(adjusting p H to 3.2 with trifluoroacetic acid):methanol-acetonitrile(50∶ 50) = 80∶ 20 with the flow rate of 1.0 ml·min-1,the detection wavelength was 225 nm,the column temperature was 30℃ and the injection volume was10 μl.Results:The linear range was 0.040 3 mg · ml-1-0.120 8 mg·ml-1(r = 1.000 0).The average recovery was 100.2%(RSD = 0.39%,n = 9) without interference from the excipients.Conclusion:The method is accurate,rapid and reproducible,which can be use in the determination of favipiravir tablets.
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