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The influence of Soluble granules of Bu Sui Sheng xue on IL-1β、IFN-γ、TNF-α expression level of chronic aplastic anemia patients

Sun Weizheng,et al The Fist Affiliated Hospital of Heilongjiang university of Traditional Chinese nedicine harbin,150040 China  
Objective:To observe the influence of Soluble granules of Bu Sui Sheng xue on IL-1β、IFN-γ、TNF-α expression level of chronic aplastic anemia(CAA) patients. Methods:By means of advanced modern medical experiments enzyme linked immunosorbent assay(ELISA) and radioimmunoassay(RIA),we detected the level of IL-1β、IFN-γ、TNF-α in blood serum of CAA patients before and after treatment with Soluble granules of Bu Sui Sheng xue,and compared with control group and normal group. Results:The levels of IL-1β、IFN-γ、TNF-α of CAA patients have remarkable difference compared with normal group(P0 01). After the treatment with Soluble granules of Bu Sui Sheng xue,there is remarkable difference in the levels between treatment group and control group(P0 05). Conclusion:The Soluble granules of Bu Sui Sheng xue can enhance the IL-1β level,decrease the IFN-γ、TNF-α level,and adjust the disturbance of immune function.
【Fund】: 黑龙江省教育厅资助课题 (项目编号 10 5 1115 7) ;; 黑龙江中医药管理局立项课题
【CateGory Index】: R259.5
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【References】
Chinese Journal Full-text Database 2 Hits
1 SUN Wei-wei1,SUN Qiang2,WANG Wei3,SUN Wei-zheng4 Author's address:1.Jiamusi Central Hospital,Jiamusi 154002;2.Jia musi College,Heilongjiang University of Chinese Medicine,Jiamusi 154002;3.Tradition Chinese Medicine Institute of Heilongjiang,Harbin 150036;4.Heilongjiang University of Chinese Medicine,Harbin 150040;Effects of Marrow-Supplementing and Blood-Engendering Granule at different dosage on the peripheral blood cells and bone marrow of mice with aplastic anemia[J];中医药信息;2008-06
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【Co-citations】
Chinese Journal Full-text Database 8 Hits
1 YU Yougui1),WEI Kemin2).1)Puji Hospital of Taizhou,Taizhou 225300,Jiangsu;2)Zhejiang University of Chinese Medicine;The change of IFN-γ and TNF-α level in peripheral blood of mice with immune-mediated aplastic anemia[J];临床医学;2008-02
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4 LI Hai-xia,ZHAO Fing-jun,SUN Wei-zheng;The study of the effects and mechanism of the soluble granules of Busui shengxue to Chrouic aplastic anemia[J];中医药信息;2005-02
5 ;The Influence of Blood-Engendering Granule to Bone Hematopoietic Progenitor Cell C-kit and CXCR_4 Receptor in Chronic Aplastic Anemia Patients[J];中医药学刊;2004-06
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7 Sun Weizheng,et al The Fist Affiliated Hospital of Heilongjiang university of Traditional Chinese nedicine harbin,150040 China;The influence of Soluble granules of Bu Sui Sheng xue on IL-1β、IFN-γ、TNF-α expression level of chronic aplastic anemia patients[J];中医药信息;2002-05
8 SUN Weizheng,YU Zhuang,TIAN Jing,et al. 1The First Affiliated Hospital of Heilongjiang University of TCM,Harbin Heilongjiang 150040;The experiment study on the treatment to the apoptosis of hematopoietic stem cell of chronic aplastic anemia with the soluble granules of Busui Shengxue(补髓生血冲剂)[J];中国中西医结合急救杂志;2001-03
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1 SUN Wei-zheng1,WANG Jin-huan2,SUN An-tao2 1. Affiliated No 1 Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040; 2. Heilongjiang University of Chinese Medicine, Harbin 150040;Effects of Marrow-supplementing and Blood-engendering Granule on vla-6/cd_(49f) in patients of chronic aplastic anemia[J];中医药学报;2007-03
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