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《Information on Traditional Chinese Medicine》 2004-01
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The study of pharmacokinetics on oxymatrine with transdermal drug delivery

WANG Jian-ming,ZHOU Yong-qiang,CHENG Li-hua,et al  
The oxymatrine is one of the main alkaloids Sophora feavescens.It has the effect of amts-arrhythmic. The oxymatrine showed to be double-compartment model after transdermal drug delivery.It's equation of pharmacokinetics is. C=-4.44928·e -0.209479t+3.65729·e -0.119990t +0.79199·e -0.029358t In which,Tp is 8.88 hours;Gmax is 1.198μg/ml,and AUC is 36.217(μg/ml)·h.At the same time,HPLC figures showed that the oxymatrine did not transform to matrine after transdermal drug delivery. Author's address:Heilongjian University of Traditional Chinese Medicine, Harbin 150040,China
【Fund】: 黑龙江省科委攻关课题 (GB0 2C1 1 0 )
【CateGory Index】: R285
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