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《Information on Traditional Chinese Medicine》 2008-01
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Effect of big Chuanxiong prescription extraction on preventing learning and memory dysfunction of vascular dementia rats

ZHAO Ying,WANG Wei,ZU Ying,et alHarbin Commercial University,pharmacy faculty,Harbin 150076,Chin  
Object: To study the effect of big Chuanxiong prescription extraction on preventing learning and memory dysfunction of vascular dementia rats.Methods: The models were made by permanent occlusion of bilateral common carotid arteries.Use shuttle box test to measure the learning and memory ability of each group.Results: Compared with model group,the number of electric shock of middle dose extract of big Chuanxiong prescription group decreased significantly(p0.01) and the time of electric shock also decreased significantly(p0.05) with the time of active escape responsbility increased(p0.01).The number of electric shock of low dose extract of big Chuanxiong prescription group decreased significantly(p0.001),the time of electric shock decreased(p0.05) and the time of active escape-respons bility increased(p0.05).Conclusion: The middle and low dose extract of big Chuanxiong prescription can prevent learning and memory dysfunction of vascular dementia rats.
【Fund】: 黑龙江省科技攻关项目(GC03C614-1)
【CateGory Index】: R285.5
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