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Experiment study on the regulating of the cytochrome P450 aromatase (P450arom) mRNA on perimenopausal natural aging rat ovarian with Chinese medicine Yikunning Perscription

ZHANG-Guangmei,ZHANG-Yangyang,QI-Qunyan, et al.1.1st Hospital of Harbin medical university department of neurology,Harbin,Heilongjiang 150001,China;2. Heilongjiang Uiversity Of Chinese Medicine,Harbin,Heilongjiang 150040,China  
To study the expression and significance of the cytochrome P450 aromatase (P450arom) mRNA on perimenopausal natural aging rat ovarian. Methods: Select thirty-two wistar rats which are perimenopausal female and during eleven to thirteen months old. Then they were randomly divided into model group, Yi Kun Ning-group and the control group of western medicine. In addition, select ten young rats which are four months old as the young control group to detect the expression of P450arom mRNA on the ovarian with in situ hybridization. Results: P450arom mRNA express negatively or weakly on ovarians in the model group and express strongly positively on ovarians in the young group.The difference between the two groups is statistically significant (P 0.01).But Yi Kun-ling group and the control group of western medicine have positive expression, they have statistically significant differences compared with the model group were (P 0.01). Conclusion: The benefits of Chinese medicine Yi Kun Ning would rather promote the expression of P450arom mRNA on rat's ovarian to estrogen synthesis.
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