In vivo study on targeted ultrasound imaging of artery thrombus
XIA Hong mei *, GAO Yun hua, BIAN Ai na, LIU Ping, TAN Kai bin, LIU Zheng(Department of Ultrasound, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China)
Objective To study method of non obstructive thrombosis in artery, and to evaluate the enhancement effect of the thrombus targeted ultrasound contrast agent on acute thrombus in normal rabbit abdominal aorta. Methods Non obstructive thrombus resulted with FeCl 3 in abdominal aorta of 30 rabbits was formatted. Ultrasound images were obtained before and after administration of microbubbles. Healthy rabbits were injected contrast agent at ear by intravenous bolus injection of the albumin targeted and non targeted ultrasound contrast agent in a dose of 0.04 ml/kg, respectively. The images were qualitatively assessed by three independent observers to determine the contrast enhancement effect of acute thrombus as grade 0 (no enhancement), grade 1 (slight enhancement effect)and grade 2 (obvious enhancement effect). Results Non obstructive thrombosis in artery was formatted successfully in 29 cases. After the albumin targeted ultrasound contrast agent was injected, there were 18 cases whose thrombus were enhanced brilliantly as grade 2 while only 1 case as grade 1. The obviously enhanced effect of the acute thrombus lasted more than 10 minutes. While after non targeted ultrasound contrast agent was injected in 10 cases, the clots were generally difficult or impossible to detect ( P 0.01). Conclusion Method of non obstructive thrombus resulted with FeCl 3 in abdominal aorta is convenient. Thrombus targeted albumin microbubbles can improve ultrasound imaging of acute thrombus in rabbit abdominal aorta.