Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Medical Imaging Technology》 2005-01
Add to Favorite Get Latest Update

Central sensitivity of oral glucose tolerance test in human subjects with different body weights

CHEN Min 1,2* , ZHANG Yun ting 2, ZHANG Tie mei 3, ZHOU Cheng 1, WU Xiao meng 3, CAI Kui 1, YANG Zheng han 1, WANG Wen chao 1, ZHAO Wei feng 1, LI Sa ying 1, WANG Zhi 1(1.Department of Radiology, 3.Institute of Gerontology, Beijing Hospital, Beijing 100730, China; 2.Department of Radiology, General Hospital Tianjin Medical University, Tianjin 300070, China)  
Objective To investigate central response of hypothalamus to oral glucose tolerance test. Methods The signal of hypothalamus was monitored by fMRI for 60 minutes in 20 persons with two types of body weight (10 obese subjects and 10 normal body weight subjects) after oral glucose intake. Normal body weight volunteers underwent repeat fMRI scan after consuming an equivalent amount of water without glucose on a separate day. The procedure for fMRI scan with water intake was the same as for glucose ingestion. Results Both normal and obese subjects demonstrated an inhibition of fMRI signal after glucose intake, but the inhibition was attenuated and delayed in obese subjects compared with that in normal subjects. The area of hypothalamus in normal subjects demonstrated no significant response after oral water ingestion. Conclusion Hypothalamus response to glucose loading in normal and obese human is different. The glucose induced central sensitivity of hypothalamus is attenuated in obese subjects.
【Fund】: 国家自然科学基金面上项目资助 (C30 370 4 32 )。
【CateGory Index】: R445.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved