~1H MRSI and MRI volumetric measurement in temporal lobe epilepsy
WANG Liang 1, LI Kun cheng 1* , LI Yong jie 2, LU De hong 3, WANG Yu ping 4, ZHANG Guo jun 2(1.Department of Radiology, 2.Department of Functional Neurosurgery, 3.Department of Pathology, 4.Department of Neurology, Xuanwu Hospital, Capital University of Medical Sciences, Beijing100053, China)
Objective To investigate the ability of 1H MR spectroscopic imaging ( 1H MRSI) and MRI volumetric measurement in the lateralization of temporal lobe epilepsy (TLE). Methods Conventional MRI and 1H MRSI were performed in 13 patients with electroencephalogram (EEG) defined unilateral TLE and 13 normal subjects, the metabolic peak ratio of N acetylaspartate (NAA), Creatine (Cr), Choline (Cho) and the volume of hippocampal formation (HF) were measured. Results Hippocampal atrophy was found in 8 patients of TLE. The NAA/Cr and NAA/Cho+Cr were significantly lower in the ipsilateral hippocampus than that of the contralateral and control's hippocampus (the former: F =5.187, P =0.012;the later: F=6.731,P =0.004). The NAA/Cr in the ipsilateral temporal neocortex was significantly lower than that of contralateral temporal neocortex. The sensitivity of lateralization was 61.5% with MRI volumetric measurement, 84.6% with 1H MRSI combining hippocampus and temporal neocortex findings. Conclusion Both MRI volumetric measurement and 1H MRSI are effective tools for lateralization of TLE. The 1H MRSI discovers more extensive metabolic abnormality in temporal lobe, and improves the sensitivity of lateralization.
【CateGory Index】： R445.2