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《Chinese Journal of Medical Imaging Technology》 2005-01
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MR diffusion weighted imaging in the classification of gliomas

MIAO Yan wei 1, HE Li yan 2, ZHANG Jing wen 1, SONG Qing wei 1, WU Jian lin 1* (1.Department of Radiology, First Hospital, Dalian Medical University, Dalian 116011, China; 2.Beijing Tongren Hospital of Capital Medical University, Beijing 100083, China)  
Objective To investigate the clinical value of DWI in the classification of gliomas. Methods Thirty seven patients with histologically proved gliomas underwent routine and diffusion weighted imaging. Comparisons of apparent diffusion coefficients (ADC) and exponential diffusion coefficients (EDC) were done among tumor parenchymas, necrosis or cystic areas, peripheral edema regions and normal tissues. Results The ADC or EDC of high grade gliomas were respectively lower or higher than those of low grade ones ( P ≤0.05). When a threshold value of 12.60×10 -4 mm 2/s for ADC was selected for grading of gliomas, 87.51%, 73.17%, 91.79% and 88.24% for the sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were achieved, respectively. The ADC (EDC) in peripheral edema regions of high grade gliomas were significantly lower (higher) than those of low grade ones ( P ≤0.05). ADC threshold value of 14.50×10 -4 mm 2/s for differentiation between high and low grade gliomas obtained 86.75%, 80.00%, 76.77% and 86.67% for the sensitivity, specificity, PPV and NPV, respectively. Conclusion The ADC (EDC) combined with routine MRI findings is of clinical application value in the classification of gliomas.
【CateGory Index】: R739.4
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