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《Chinese Journal of Medical Imaging Technology》 2008-07
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A comparative experimental study of quantitative diagnosis of fatty liver by biochemistry,ultrasonography,CT and ~1H MRS

SU Zhong-zhen1, SHAN Hong1, HE Bing-jun1, LV Wen-tian1, MENG Xiao-chun1, WANG Jin1, ZHU Kang-shun1, YANG Yang2, CHEN Gui-hua2(1.Department of Radiology, 2.Department of Liver Transplantation, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China)  
Ojective To compare the values of biochemistry, ultrasonography, CT and 1H MRS in the quantitative diagnosis of fatty liver. Methods Forty-five healthy New Zealand rabbits were randomly divided into one normal control and three experimental groups. Hepatic steatosis models were established by giving high fat, high sugar diet with drinking water containing five percent ethanol. Eighteen variable indexes were measured by biochemical examination, ultrasonography, CT, 1H MRS. Univariate analysis, LSD test, and correlation analysis were used. Results By statistical analysis, there were ten variable indexes with significant differences among the groups and correlated with hepatic steatosis grade, which were serum AST, TC, TG, ultrasound attenuation coefficient, liver CT value, liver-muscle density ratio, 1H MRS fat peak value, fat peak area, fat-water peak area ratio, fat percentage. Among them serum TC, ultrasound attenuation coefficient, liver CT value and 1H MRS fat peak area had the highest degree of relationship with hepatic steatosis grade. The correlation coefficients of biochemical examination, ultrasonography, CT, 1H MRS in diagnosis of fatty liver were 0.886, 0.483, -0.764, 0.558, respectively. Conclusion The values of biochemical examination and CT in the quantitative diagnosis of fatty liver are higher than ultrasonography and 1H MRS.
【Fund】: 广东省自然科学基金(06021217)
【CateGory Index】: R575.5;R445
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1 NAN Yue-min~*,YAO Xi-xian,GUO Rui-jun,WU Wen-juan,YIN Chun-xia,ZHEN Jing-qin.~*Department of Integrated Traditional Chinese and Western Medicine on Hepatology,the Third Hospital of Hebei Medical University,Shijiazhuang 050051,China;Study of ultrasonic integrated backscatter on experimental hepatic steatosis model in rabbits[J];Chinese Journal of Ultrasonography;2005-12
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