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《Chinese Journal of Medical Imaging Technology》 2008-07
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An experimental study on the value of MR conventional series and DWI in diagnosis of liver tumor

FAN Yi2, LIU Jing-hua2, HU Wei-dong2, XIANG Li2, LIANG Bing2, ZHANG Xue-lin1(1.Medical Imaging Center, Nangfang Hospital of Southern Medical University, Guangzhou 510515, China;2.Department of Radiology, Longgang Central Hospital of Shenzhen, Shenzhen 518116, China)  
Objective To investigate the values of MR DWI in diagnosing hepatic carcinoma by studying the appearances of rabbit VX2 hepatic carcinoma in MR T1WI, T2WI and DWI series at different tumor transplanted times. Methods The metastatic rabbit VX2 hepatic carcinoma models were presented in thirty New Zealand white rabbits. VX2 carcinoma masses were injected into the liver using percutaneous puncture inoculation method in guiding by CT scanner in each group. MR T1WI, T2WI, T2WI SPIR and DWI were performed in all experimental animals at 4th, 1, 2 and 3 weeks after implantation. The diagnosis rates of different methods in different time were observed and analyzed. Results Of 30 rabbits, 25 were transplanted VX2 hepatic carcinoma. The success rate of carcinoma transplanted was 81.25%. The tumor locus was found in every examination series at 4th after the implantation. The diagnosis rates of DWI, T1WI, T2WI and T2WI SPIR were 80%, 60%, 72% and 72% respectively. No statistical difference was found. The diagnosis rates were 100% in all MR series at 1, 2 and 3 week after implantation. In comparison of diagnosis rates between 4 days and 1 to 3 week after the tumor implantation in different series, the significant difference was only observed on DWI series and no difference on other series. Conclusion MR DWI is a sensitive series in examination of liver tumor, influenced little by tumor blood supply, and will be used in diagnosis of liver tumor more and more.
【CateGory Index】: R735.7
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