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《Chinese Journal of Medical Imaging Technology》 2008-07
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Comparative study of magnetic resonance diffusion tensor imaging in clinically isolated syndrome and relapsing-remitting multiple sclerosis

LIU Ya-ou1, YU Chun-shui1, LI Kun-cheng1, LIN Fu-chun2, DUAN Yun-yun1, QIN Wen1, WANG Hui1(1.Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; 2.Institute of Physics and Mathematics, Chinese Academic of Science, Wuhan 430071, China)  
Objective To investigate whether normal appearing brain tissue (NABT) abnormalities occur in patients with clinically isolated syndrome (CIS) and how serious it is comparing to multiple sclerosis (MS), and to find the relationships between DTI indices of lesions, NABT and clinical status to reveal the possible pathologic mechanisms and offer evidences for treatment. Methods Ninteen patients with CIS, 19 clinically diagnosed relapsing-remitting MS patients and 19 sex- and age-matched healthy volunteers were chosen as subjects. Images were obtained using Siemens 1.5T magnetom sonata scanner, including conventional MRI and DTI. The volume, mean diffusivity (MD) and fractional anisotropy (FA) of lesions, DTI histograms of whole brain, NABT were obtained. The mean value, peak height, peak location of the histogram were used for analysis. All data were statistically processed with SPSS for Windows (version 11.5). Results No significant differences were found in the brain volume, DTI indices of lesions among control, CIS and RRMS. Comparing with control, CIS patients showed significantly higher whole brain and NABT average MD, lower FA (P0.05), however, which is lower in average MD and higher in FA than RRMS (P0.05). The peak height of NABT average MD histogram was significantly lower in CIS than control (P0.05), but higher than RRMS. The peak location of NABT average FA histogram in RRMS, CIS and control was from left to right (P0.05). There was no correlations between DTI indices and EDSS scores in patients with CIS. Moderate correlations between lesion FA (r=-0.566, P=0.012), average MD in whole brain (r=0.497, P=0.030), NABT (r=0.692, P=0.001) were found in patient with RRMS. Conclusion Whole brain contains lesion and NABT abnormalities do occur in CIS which can be detected by DTI sensitively. The lesions are similar with MS, however, the underlying pathological changes in NABT are milder than MS.
【Fund】: 北京市自然科学基金资助项目(7042026)
【CateGory Index】: R744.5
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