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《Chinese Journal of Medical Imaging Technology》 2008-07
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Whole-brain voxel-based MRI morphometric study of gray matter in medial temporal lobe epilepsy

YU Ai-hong1, LI Kun-cheng1, LI Lin2, SHAN Bao-ci2, WANG Yu-ping3(1.Department of Radiology, 3.Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China; 2.Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China)  
Ojective To analyze whole-brain gray matter changes in medial temporal lobe epilepsy (MTLE) using voxel-based morphometry (VBM). Methods We studied 23 patients with MTLE and 13 age- and sex-matched healthy control subjects using VBM on T1 weighted 3D datasets. The seizure focus was right sided in 11 patients and left sided in 12. The data were collected on a 1.5T MR system and analyzed by SPM 99 to generate gray matter density map. Results Voxel-based morphometry revealed reduced gray matter density in MTLE extended not only in the hippocampus ipsilateral to the seizure focus, but also in the contralateral hippocampus and other limbic areas such as the thalamus and the cingulum, as well as extra-limbic areas, particularly the frontal lobe and the cerebellum. Conclusion VBM is a simple and automatic approach that is able to identify diffuse gray matter abnormalities including hippocampus and extra-hippocampus in MTLE.
【CateGory Index】: R742.1
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