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《Chinese Journal of Medical Imaging Technology》 2010-01
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Quantitative analysis of normal pancreas and pancreatic carcinoma with dynamic contrast-enhanced MR imaging on 3.0T system

MA Xiao-hong,ZHAO Xin-ming,OUYANG Han,ZHANG Hong-mei,ZHOU Chun-wu (Department of Diagnostic Imaging,Cancer Hospital,Chinese Academy of Medical Sciences,Peking Union Medical College,Beijing 100021,China)  
Objective To quantify the perfusion parameters of normal pancreas and pancreatic carcinoma with three-dimension(3D)fast spoiled gradient echo dynamic contrast enhanced(DCE)MRI on 3.0T MR system,and to assess the value of 3D DCE-MRI in the diagnosis of pancreatic carcinoma.Methods Thirty-four patients with pathology verified pancreatic carcinoma and 31 control subjects with normal pancreas(without pancreatic diseases)underwent DCE-MRI with 3D LAVA sequence of ten phases.The data were processed on ADW 4.2 workstation.The perfusion parameters of the head,body and tail of normal pancreas,together with lesion and non-lesion area of pancreatic carcinoma were measured and statistically analyzed,including signal enhancement ratio at 30 s after injection(SER 30),signal enhancement ratio at 90 s after injection(SER 90),positive enhancement integral(PEI),time to peak(TTP)and maximum slope of increase(MSI).Results There was no significant perfusion difference among head,body or tail of normal pancreas(P 0.05).The difference of SER 30,PEI,TTP and MSI between lesion and non-lesion region of carcinous pancreas was significant(P 0.05).The TTP between normal pancreas and the non-lesion region of carcinous pancreas was significantly different(P 0.05).Conclusion Normal pancreas has no regional perfusion difference.The data from DCE-MRI provide reliable information for the diagnosis of pancreatic cancer,and for the assessment of the invasion of pancreatic carcinoma.The difference in TTP between the normal pancreas and non-lesion region of carcinous pancreas suggest the existing of potential lesions.
【Fund】: “十一五”国家科技及支撑课题(2007BAI05B05)
【CateGory Index】: R735.9
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