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《Chinese Journal of Medical Imaging Technology》 2010-01
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Utility of 3.0T MR diffusion-weighted imaging in diagnosis of pancreatic carcinoma

ZHANG Hong-mei,ZHAO Xin-ming,OUYANG Han,MA Xiao-hong,ZHOU Chun-wu (Department of Diagnostic Imaging,Cancer Hospital,Chinese Academy of Medical Sciences,Beijing 100021,China)  
Objective To evaluate the ability of diffusion-weighted imaging(DWI)and the apparent diffusion coefficient(ADC)value in diagnosis of pancreatic cancer at 3.0T MR.Methods The diffusion-weigted sequences with b=800 s/mm 2 were performed in 30 patients of pancreatic cancer confirmed pathology,and in 30 control subjects with normal pancreas as well.ADC value of the cancer,pericancerous tissue and normal pancreas were recorded and statistically analyzed with ANOVA and ROC analysis.Results The mean ADC value of cancer,pericancerous tissue and normal pancreas was(1.494±0.273)×10-3 mm 2/s,(1.631±0.281)×10-3 mm 2/s and(1.778±0.237)×10-3 mm 2/s,respectively.ADC value of pancreatic cancer was significant different from that of the normal pancreas,while there was no significant difference between pancreatic cancer and pericancerous tissue.The one-side upper limit of 95% confidence interval of mean ADCs(1.622×10-3 mm 2/s)was adopted as the point to diagnosis of pancreatitis.The area under ROC curve was Az=0.800.Conclusion ADC values are helpful to differential diagnosis of pancreatic cancer and normal pancreas.DWI may be do some contribution to the diagnosis of pancreatic cancer.
【Fund】: “十一五”国家科技及支撑课题(2007BAI05B05)
【CateGory Index】: R735.9
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