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Phantom research of threshold segmentation for PET/CT target volume delineation in radiation treatment planning

LIN Lin1,ZHENG Rong1,2*,WANG Yi-bin2,GENG Jian-hua1,2,WU Ning2 (1.Department of Nuclear Medicine,2.PET/CT Centre,Cancer Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100021,China)  
Objective To explore the threshold in the phantom with hot spheres,and to get the method to define a biological target volume contour with integrated PET/CT.Methods Spheres with volumes ranging from 0.5 to 16.0 ml and target/background activity concentration(T/N) ratio of 164.13∶1,32.96∶1 and 12.69∶1,as well as those without background were established.The relationship between the threshold and the target volume,target/background activity concentration ratio and imaging mode was observed.Results The threshold of the spheres with the volumes ≥2.0 ml ranged from 36.80% to 43.70%(average 39.59%).The threshold of the spheres with the volumes 2.0 ml ranged from 39.30% to 50.90%(average 45.98%).There was no significant difference among the average thresholds of spheres with volumes ≥2.0 ml(P0.05).The thresholds of spheres with the volumes 2.0 ml significantly decreased as the volumes increased(P=0.015).When the T/N ratio12.69∶1,the thresholds of spheres were not obviously affected by the change of the T/N ratio(P0.05).There was no significant difference of the threshold value between 2D and 3D imaging mode in the same time.Conclusion The thresholds of the spheres with the volumes ≥2.0 ml were not changed obviously as the volumes increased,so the threshold 40% is recommended as the contour threshold.
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