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《Chinese Journal of Medical Imaging Technology》 2010-09
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Pulmonary HRCT findings of Langerhans cell histiocytosis in infants

LI Su-rong1, CHE Li2, YUAN Xin-yu1(1.Department of Radiology, 2.Department of Medicine, Peking University Teaching Hospital-Capital Institute of Pediatrics, Beijing 100020, China)  
Objective To study the features of lung high-resolution CT images of Langerhans cell histiocytosis (LCH) in infants, and to analyze the relationship of the CT manifestations with the age at onset and the course of the disease. Methods HRCT of lung for 23 LCH patients were reviewed retrospectively. All patients were divided into two groups (interstitial group, nodule and [or] air-filled cyst group) based on the findings of HRCT. The age at onset and the course of disease were compared between the two groups. Results Abnormal HRCT findings were observed in 20 patients (86.96%), including interstitial lung disease, solitary or diffuse nodules and air-filled cysts. The median course of the two groups was 3.0 (0.7—12.0) months and 6.0 (3.0—24.0) months, respectively. There was significant difference between two groups (P0.05). Totally 15 patients were followed up with HRCT after chemotherapy, 12 patients returned to normal, 2 patients remained abnormalities, and one patient died. Conclusion HRCT findings of LCH in infants includ interstitial changes, nodules and (or) air-filled cysts. Interstitial changes are the major abnormality in the early stage, and then evolute to nodular and (or) air cystic patterns with aggravation. The patients without diffused nodules and (or) air-filled cysts in the lung would have good prognosis.
【CateGory Index】: R816.92
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