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《Chinese Journal of Medical Imaging Technology》 2011-01
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CT perfusion imaging on steroid-induced avascular necrosis of the femoral head of rabbits

SUN Na1,LIU Xiu-juan1,JIANG Hong2(1.CT Room,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China;2.Department of Imaging,Heilongjiang Province Hospital,Harbin 150001,China)  
Objective To observe CT perfusion imaging(CTPI) and pathological changes of steroid-induced avascular necrosis of the femoral head(SANFH) in different stages.Methods Thirty Japanese white rabbits were examined with CTPI in the same method in the 2nd,4th,6th,8th and 10th week after injection of Hydrocortisone.Time-density curves(T-DC) was depicted and blood flow(BF),blood volume(BV),mean transit time(MTT) of femoral head in different stage of ischemia were analyzed.After examination,the rabbits were killed,the samples were examined histologically,and the number of empty lacuna and capillary vessels were analyzed.Results BF and BV of femoral head decreased during earlier period(2nd and 4th week),obviously with prolongation of injection(6th and 8th week),but BF and BV increased in the 10th week.MTT did not change obviously.The number of empty lacuna and capillary vessel decreased while earlier period increased.Conclusion CTPI can reflect the blood changes of early stage SANFH.
【Fund】: 黑龙江省自然科学基金面上项目(D2007-47)
【CateGory Index】: R681.8;R816.8
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