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《Chinese Journal of Medical Imaging Technology》 2011-01
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Contrast-enhanced ultrasonic evaluation of characteristics of renal VX2 tumor in rabbit models

ZHANG Da-kun1,LI Meng1,CHEN Min1,DONG Bao-wei2,LIANG Ping2,YU Xiao-ling2,WANG Xi-you3(1.Department of Ultrasound,the 302nd Hospital of PLA,Beijing 100039,China;2.Department of Interventional Ultrasound,3.Department of Urology,Chinese PLA General Hospital,Beijing 100853,China)  
Objective To investigate the value of contrast-enhanced ultrasound(CEUS) in monitoring and evaluating the growth characteristics of VX2 renal tumor in rabbit models.Methods Twenty rabbits were operated and VX2 carcinoma was transplanted into the kidney using tumor tissue embedding method.Then rabbits were divided into 4 groups randomly,and CEUS examimation were made 1,2,3 and 4 weeks after the transplantation,respectively.The rabbits were killed immediately after CEUS,and the kidney tumors were resected for pathological examination.Results All the models were established successfully.There was no statistical difference between the volume of VX2 tumors measured with CEUS and pathology(all P0.05).There was consistency between the two methods.All VX2 tumors showed hypoechoic enhancement in CEUS,and the enhancement was lower than renal parenchyma.In arterial phase VX2 tumors showed different enhancement patterns,tumors post-transplanted 1—2 weeks were mainly homogeneous enhancement(7/10),tumors post-transplanted 3—4 weeks were mainly peripheral enhancement(8/10).Conclusion CEUS can accurately measure the diameter of the VX2 renal tumor and display the intratumoral vascularity in rabbit models.CEUS has important value in monitoring the growth and evaluation the characteristics on renal VX2 tumor in rabbits.
【CateGory Index】: R737.11
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