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《Chinese Journal of Medical Imaging Technology》 2011-01
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Altered resting-state functional connectivity and anatomical connectivity of cerebellum in schizophrenia

LIU Hu1,FAN Guo-guang1,XU Ke1,KONG Ling-tao2,TANG Yan-qing2,LIU Ying2(1.Department of Radiology,2.Department of Psychiatry,the First Hospital of China Medical University,Shenyang 110001,China)  
Objective To observe the differences of functional connectivity and anatomical connectivity of cerebellum between schizophrenic patients and normal controls with combining resting-state functional MRI(fMRI) and diffusion tensor imaging(DTI).Methods Both fMRI during rest and DTI were performed on 10 patients and 14 healthy subjects using GE 3.0 T Signa MR scanner.Resting-state functional connectivities of the bilateral cerebellum were separately analyzed with selecting seed regions in cerebellum.The integrity of white matter fiber in bilateral middle cerebellar peduncles was evaluated using fractional anisotropy(FA).Two sample t-test was used to detect differences between patients and normal controls,and correlation test was taken to analyze the correlation between the strength of functional connectivity and anatomical connectivity.Results ①Compared with controls,the left cerebellum showed reduced functional connectivities to some regions in patients,such as bilateral lingual gyrus,right middle frontal gyrus,bilateral supramarginal gyrus aod left cerebellum(P0.001,uncorrected).The right cerebellum also showed reduced functional connectivity to some regions in patients,such as bilateral lingual gyrus,left precentral gyrus and left supramarginal gyrus(P0.001,uncorrected).②The FA of the left middle cerebellar peduncle significantly reduced in patients(P0.05).③There was significantly positive correlation between the connective strength of right cerebellum-right lingual gyrus and the FA of the right middle cerebellar peduncle in patients with schizophrenia(r=0.84,P0.05).Conclusion The multimodal imaging approaches presently used provide a new avenue to understand the role of cerebellum in the pathophysiology of schizophrenia.Meanwhile,the concurrence of the functional disconnectivity and damaged anatomical connectivity between the cerebellum and other regions in schizophrenia suggest that the functional-anatomical relationship need to be further investigated.
【CateGory Index】: R445.2;R749.3
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