Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Medical Imaging Technology》 2011-01
Add to Favorite Get Latest Update

Application of multivoxel ~1H-magnetic resonance spectroscopy with different echo times in lesions and normal-appearing white matter of multiple sclerosis

CHEN Xuan,LI Yong-mei,OUYANG Yu,LV Fa-jin,ZENG Chun,WANG Zhong-ping(Department of Radiology,the First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China)  
Objective To explore the value of multivoxel two-dimensional proton magnetic resonance spectroscopy(2D 1H-MRS) with long and short echo time(TE) sequences in the lesions and normal-appearing white matter(NAWM) of patients with multiple sclerosis(MS).Methods Both 50 patients with relapsing-remitting MS(RRMS) and 20 healthy volunteers underwent conventional MR as well as long TE and short TE sequences of multivoxel 1H-MRS.The N-acetylaspartic acid(NAA),choline(Cho),creatine(Cr),lipid(Lip),lactic acid(Lac) and myo-inositol(mI) peaks were measured in each region of interest,and the changes of NAA/Cr,Cho/Cr,(Lip+Lac)/Cr and mI/Cr in the lesions and NAWM were analyzed.Results Long TE sequence showed that NAA/Cr,Cho/Cr and NAA/Cho were significantly different among the enhancing lesions,no enhancing lesions and the white matter(WM) of controls(P0.01).NAA/Cr and NAA/Cho were not significant different between the enhancing and no enhancing lesions(P0.01).Short TE sequence showed that NAA/Cr,Cho/Cr and(Lac+Lip)/Cr were significantly different among enhancing lesions,no enhancing lesions,NAWM of MS patients and WM of the controls(P0.01).There was no significant difference in NAA/Cr and Cho/Cr of the lesions between long TE and short TE sequences(P0.01),but short TE sequence was superior to detect the Lip,Lac and mI peaks.Conclusion Both long and short TE sequences can detect metabolic abnormalities in the lesions and NAWM of MS patients.Long TE can be used to detect the main metabolites,while short TE can detect more metabolites than long TE,both of them can provide important information for pathology of MS.
【Fund】: 重庆市卫生局资助项目(2009-2-311、2010-2-004)
【CateGory Index】: R744.51
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 SU Zhong-zhen1, SHAN Hong1, HE Bing-jun1, LV Wen-tian1, MENG Xiao-chun1, WANG Jin1, ZHU Kang-shun1, YANG Yang2, CHEN Gui-hua2(1. Department of Radiology; 2. Department of Liver Transplantation, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, China);Comparison on the values of STEAM and PRESS sequences in ~1H MRS quantitative evaluation of fatty liver[J];Chinese Journal of Interventional Imaging and Therapy;2008-02
2 WANG Jia,FAN Guo-guang(Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 110004,China);Current and progressive investigations of ~1H-MRS study on glioma-associated epileptogenesis[J];Chinese Journal of Medical Imaging Technology;2008-S1
Chinese Journal Full-text Database 1 Hits
1 ZHAO Li-ming,SONG Bin,CHEN Guang-wen,YUAN Fang,HUANG Zi-xing,YANG Nin-jing.Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China;Value of ~1H-MR Spectroscopy for Quantification of Hepatic Steatosis on 3.0 T MR System[J];Chinese Journal of Bases and Clinics in General Surgery;2010-01
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 LIU Ai-jun, LI An-min, FU Xiang-ping, et al . Department of Neurosurgery, The First Affiliated Hospital, General Hospital of PLA, Beijing 100037, China;Analysis of Causes of Epileptic Seizure in Patients with Supratentorial Gliomas[J];Chinese Journal of Clinical Neurosurgery;2006-08
2 CHEN Qian-xue,GUO Xi-xiong,TIAN Dao-feng,et al . Department of Neurosurgery,Renming Hospital,Wuhan University,Wuhan Hubei 430060,China;Clinical Study of Resection of Epileptogenic Gliomas under Monitoring by Cortical Electroencephalogram[J];Chinese Journal of Clinical Neurosurgery;2007-08
3 FAN Guo-guang~*, ZANG Pei-zhuo, JING Feng-dong, WU Zhen-hua,GUO Qi-yong. ~*Department of Radiology, Second Hospital, China Medical University, Sheyang 110004;Usefulness of diffusion-weighted and perfusion-weighted MR in mouse C6 gliomas:correlation with histopathology[J];Chinese Journal of Radiology;2005-06
4 FAN Ming-xia, TIAN Jian-ming, LU Jian-ping, JIN Ai-guo, ZENG Hao (Department of Radiology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China);Preliminary evaluation of fatty liver in rats by in vivo ~1H MR spectroscopy[J];Chinese Journal of Medical Imaging Technology;2004-10
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved