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《Traditional Chinese Drug Research and Clinical Pharmacology》 2011-03
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Anti-influenza Effect of Essence of Chicken in Mice Loaded with Restraint Stress

WANG Congzhi,CHEN Bangtian,LI Yifang,YU Liwei,LI Weixi,HE Rongrong,KURIHARA Hiroshi(Institute of Traditional Chinese Medicine and Natural Products,Jinan University,Guangzhou 510632,China)  
Objective To study the anti-influenza virus effect of Essence of chicken(EC) in mice loaded with restraint stress.Methods Male Kunming mice were randomly divided into normal control group,virus group,model group(virus + restraint stress),positive group(ribavirin,50 mg·kg-1),low-dosage EC(12 mL·kg-1) group and high-dosage EC(24 mL·kg-1) group.Except for normal control and virus groups,all mice were given restraint stress for 18 h on the second day of medication.One day after restraint stress,mice were anesthetized by ether and infected intranasally with influenza virus H9N2 diluted in saline.During the experiment,we recorded the survivor rate and mean day to death(MDD) of mice from the day of virus infection to day 21.On day 4 of virus infection,the lung index was examined.In order to further investigate the anti-influenza virus mechanism of EC in stressed mice,we also determined the impact of EC on immune function of restraint stressed mice.Results Ribavirin and EC obviously increased the survivor rate and MDD,decreased lung index in virus infected mice loaded with restraint stress.We further found that EC could improve the immune function in restraint stressed mice through increasing thymus index,spleen index and spleen lymphocyte count,elevating the ratio of lymphocyte subset Th(CD3+CD4+) and Ts(CD3+CD8+),and improving the NK cell activity in spleen.Conclusion EC possesses anti-influenza virus effect in mice loaded with restraint stress through improving immune function.
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 1 Hits
1 LI Yi-fang, HE Rong-rong, KURIHARA Hiroshi (Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, Guangdong 510632);Anti- fatigue Effect of Nutritional Essence of Chicken[J];Pharmacy Today;2008-06
Chinese Journal Full-text Database 2 Hits
1 Cao Yong-mei Long Dao(Shanghai) Enterprise Management Co.,Ltd.(Shanghai 201103);Determination of Carnosine and Anserine Content in the Nutritional Essence of Chicken[J];The Food Industry;2013-02
2 LI Yi-fang, ZENG Huai-wei, CHEN Bang-tian, HE Rong-rong, KURIHARA Hiroshi(Institute of Traditional Chinese Medicine and Natural Products,Jinan University,Guangzhou 510632,China);Effects of Chicken Essence on Immune Activity in Restraint Stressed Mice[J];Journal of Food Science and Biotechnology;2011-01
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