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《Chinese Journal of Birth Health & Heredity》 2011-01
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Analysis on the result of 13600 pregnant women's serum triple screening test for fetal Down syndrome in second-tri-mester

TANG Hui-jing,FENG Xiao-chun,LUAN Hai-ping,YANG Su-xia.(Putuo Materal and Children Health Hospital,Shanghai,200060,China)  
Objective: To explore the relationship between the pregnant women's serum triple screening test in second-trimester and detection rate of picking out fetal Down syndrome.Method: Underwent triple screening test (alpha fetoprotein,AFP;human chorionic gonadotrophin,HCG and unconjugated estriol,uE3) by chemiluminescent immunoassay in second-trimester (15-20 weeks).using the specialized software calculated the risk of Down's.The suggestion carried on which the result bigger than 1: 380 is positive analyzing the chromosome nuclear type of the amniotic fluid.Resluts: 1281 examples screening is positive among 13600 pregnant women.In the pregnant women who volunteer to accept the amniotic fluid examination,picked out 6 examples of fetal Down syndrome,and also picked out 18 trisomy syndrome 4 examples,other unusual chromosome 6 examples.Conclusion: The pregnant women's serum triple screening test in second-trimester takes effect in screening the fetal birth defect,especially in screening trisomy syndrome.To reduce the flaw birth,the pregnant woman screening result assumes high-risk should carry on analyzing the chromosome nuclear type of the amniotic fluid.
【CateGory Index】: R714.55
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