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《THE JOURNAL OF TRADITIONAL CHINESE ORTHOPEDICS AND TRAUMATOLOGY》 1999-12
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THE PREVENTION AND TREATMENT OF RABBIT KNEE OSTEOARTHRITIS BY KIDNEY-TONIFY-ING METHOD:A Pathomorphological Observation

Gao Wenxiang;Liu Yuanlu;Li Yongsheng,et al(Liaoning College of Traditional Chinese Medicine, Shenyang 110032)  
The authors explored the pathogenesis of osteoarthritis (OA) and the feasibility of the kidney--tonifying (KT) method through observing the influence of pure KT traditional Chinese drugs (TCD) on the cartilage and the synovium in rabbit knee OA. OA models were made by injecting papaininto rabbit knee articular cavity and treated by KT TCD given through the stomach. Six weeks later, the specimens were harvested for gross observation. Then. the femoral internal condyle was taken and observed under transmission electron microscope and under light microscope afterHE, Masson and Safranin-0 staining; the synovial tissue taken from the anterior knee was observed under light microscope after HE staining. Theresults showed that the degrees of the joint chondrocyte destruction and the synovial tissue injury of the rabbit knee in KT group were significantlylowered (P 0. 10 ) and the disturbance and type-transformation of the chondral collagenous fibers were much alleviated in comparison with thoseof the model group. It was believed that KT TCD function to effectively prevent and treat experimental osteoarthritis, which verified the theory oftraditional Chinese medicine 'The kidneys govern the bone" again.
【CateGory Index】: R274
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