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《THE JOURNAL OF TRADITIONAL CHINESE ORTHOPEDICS AND TRAUMATOLOGY》 2000-01
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THE INFLUENCE OF “YOUGUI YIN” AND “LUMA PIAN” ON PLASMA ESTRADIOL AND TESTOSTERONE IN HORMONE INDUCED RABBIT FEMORAL HEAD NECROSIS: A Therapeutic effect Study

WT5BZ]Zhao Wanjun 赵万军, Xiao Luwei 肖鲁伟, Tong Peijian 童培建, et al [WT5”BX]Second Hospital Affiliated to Zhejiang TCM College, Hangzhou 310006 [WT5”BZ]  
In order to study the function of estradiol (E 2 ) and testosterone (T) in hormone induced rabbit femoral head necrosis (HIFHN) and to evaluate the preventive and therapeutic effect of the kidney Yang reinforcing plant and animal drugs “YOUGUI YIN” (YY, The Kidney Yang Reinforcing Decoction) and “LUMA PIAN” (LP, Granulae of Cornu Cervi and Hippocampus) on HIFHN, rabbit femoral head necrosis models were made by exogenous glucocorticoid induction, the plasma levels of E 2 and T in the animal models were dynamically observed and so was the preventive and therapeutic effect of the kidney Yang restoring plant and animal drugs. The results suggested that the levels of E 2 and T in HIFHN models were significantly reduced; YY antagonized E 2 reduction but could not inhibit T reduction; LP could antagonize the reduction of both E 2 and T and recover them to the balance; and the elevating amplitude of LP was greater than that of YY. The pathological results showed the therapeutic effect of LP was better than that of YY. It was believed that the hyposecretion of E 2 and T may play an important role in bone necrosis and the kidney Yang reinforcing traditional Chinese drugs function to prevent the hormonal femoral head necrosis and the animal drugs have a better therapeutic effect than the plant ones.
【CateGory Index】: R285
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