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《The Journal of Traditional Chinese Orthopedics and Traumatology》 2015-01
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Effect of Jiawei Yanghe Tang(加味阳和汤) on articular cartilage in rabbits with early knee osteoarthritis

WANG Wenbo;DONG Jianwen;YANG Zhenguo;WANG Shuqiang;WANG Lei;LIU Wenbin;Shandong University of Traditional Chinese Medicine;  
Objective: To observe the effect of Jiawei Yanghe Tang( 加味阳和汤,JWYHT) on articular cartilage in rabbits with early knee osteoarthritis. Methods: Thirty 6-month-old ordinary healthy New Zealand white rabbits were randomly divided into blank group,model group and experimental group,10 cases in each group. The early knee osteoarthritis models of right knee joint were built by modified Hulth method in rabbits of model group and experimental group. After that,the rabbits in experimental group were intragastric administrated with JWYHT,while rabbits in model group were intragastric administrated with normal saline for consecutive 4 weeks. After drug intervention,Xray examination and roughly anatomical observation were performed on knee joints. The cartilago articularis were fetched from medial tibial plateau and were sectioned for HE staining. All the samples were observed under the optical microscope and the cartilaginous changes were evaluated according to Mankin Score. Results: Symmetrical knee joint gap and smooth articular surface and no obvious hyperplasia were found in rabbits of blank group. In model group,the medial joint gap almost disappeared and the knee presented with varus deformity; and accrescent medial femoral condyle,rough medial tibial plateau and a large number of osteophytes located at medial femoral condyle and medial tibial plateau were found. In experimental group,the knee joint gap was not smooth and medial knee joint gap became narrow and a few osteophytes were found at medial femoral condyle and medial tibial plateau. In fact,less anatomical changes were found in the experimental group compared to the model group. The cartilage morphology was classified according to its degradation degree,The rabbits belonged to gradeⅠ( 9) and grade Ⅱ( 1) in blank group,grade Ⅱ( 3) and grade Ⅲ( 7) in model group,grade Ⅱ( 5) and grade Ⅲ( 5) in experimental group. Comparison showed that the blank group was the best,experimental group was good and model group was the worst in knee articular cartilage morphology( Rblank group= 5. 90,Rmodel group= 21. 35,Rexperimental group= 19. 25; χ2= 20. 524,P = 0. 000). Mankin scores of cartilago articularis was 0. 550 +/- 0. 675,7. 950 +/- 1. 535 and 4. 300 +/- 1. 337 points respectively,there was statistical difference between the 3groups( F = 89. 233,P = 0. 000). Mankin scores were lower in blank group compared to model group and experimental group( P = 0. 000,P = 0. 000),and were higher in model group compared to experimental group( P = 0. 000). Conclusion: The JWYHT can inhibit the degeneration of cartilago articularis of rabbits with early knee osteoarthritis,so it may be one of the mechanisms of action for treatment of early knee osteoarthritis.
【Fund】: 国家自然科学基金项目(81173286);; 济南市科技发展计划项目(201102063)
【CateGory Index】: R285.5
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