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《The Journal of Traditional Chinese Orthopedics and Traumatology》 2016-01
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Influence of Rivaroxaban and enoxaparin sodium on lower extremity deep venous thrombosis after total hip&knee arthroplasty and perioperative hidden blood loss

YI Chunzhi;CHEN Jinlun;LI Zhaohong;ZENG Jianchun;FAN Yueguang;The First Affiliated Hospital of Guangzhou University of traditional Chinese medicine;Guangzhou University of traditional Chinese medicine;  
Objective: To compare the influence of Rivaroxaban and enoxaparin sodium on lower extremity deep venous thrombosis( DVT) after total hipknee arthroplasty( THATKA) and perioperative hidden blood loss. Methods: One hundred and two patients( 42 males and 60 females) between the ages of 24 and 79 years( Median = 55 yrs) were recruited. Seventy two patients received THA in 80 hips and 30 patients received TKA in 33 knees. The patients were randomly divided into 2 groups,54 cases in Rivaroxaban group and 48 cases in enoxaparin sodium group. The patients in Rivaroxaban group were treated with oral application of Rivaroxaban after the surgery for anticoagulation,while the patients in enoxaparin sodium group were treated with hypodermic injection of enoxaparin sodium for anticoagulation. The lower extremity DVT and adverse reactions were observed and compared between the 2 groups after the surgery,and the blood loss were recorded and compared between the 2 groups. Results: There was no statistical difference in the actual total blood loss,dominant blood loss and hidden blood loss between the 2 groups at the 5th day after surgery( 1433. 02 + /- 565. 31 vs 1405. 13 + /- 575. 28 ml,t = 0. 246,P =0. 805; 615. 28 + /- 291. 99 vs 509. 28 + /- 308. 35 ml; t = 1. 782,P = 0. 078; 817. 74 + /- 435. 82 vs 895. 85 + /- 468. 64 ml; t = 0. 872,P =0. 385). All of the patients in the 2 groups got primary healing in the operative incisions and no lower extremity DVT and adverse reactions such as gastrointestinal bleeding were found. Conclusion: Both Rivaroxaban and enoxaparin sodium can be used as postoperative anticoagulants in patients who receive THA or TKA for they can effectively prevent lower extremity DVT with high safety,and they have similar effects on the perioperative hidden blood loss.
【CateGory Index】: R687.4
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