The deletion of p14ARF protein in human gliomas and its significance
CAO Xiaoyun, CHEN Xiancheng, ZHANG Yuling. (Department of neurosurgery, Huashan Hospital of Fudan University, Shanghai 200040)
Objective To investigate the deletion of p14ARF and its relation with clincial pathology. Method The expression of p14ARF was studied in 55 cases of glioma using streptavidin peroxidase (SP) immunohistochemical method. Results The percentage of p14ARF deletion in glioma of grade I II and those of grade III IV were 32% and 66.7%, respectively ( P 0.05). Conclusion The loss of p14ARF protein is significantly correlated with the pathologic grading of the glioma. Hence it may be an important factor of carcinogenesis and development of glioma.
【CateGory Index】： R739.41