Neutrophils in development of lung cancer and their prognostic significance
GAO Zhaoyu;LIANG Di;JIN Jing;LI Daojuan;LIU Congmin;ZHANG Yachen;HE Yutong;Cancer Institute,Fourth Hospital of Hebei Medical University;
The inflammatory reaction is the seventh major feature of the cancer, especially the neutrophils in the development and prognosis of lung cancer. This paper expounds the typing of neutrophils and their roles in the tumor microenvironment and the mechanism of regulating the growth, metastasis and angiogenesis of lung cancer through secreting various cytokines. The effects of peripheral blood neutrophils, ratio of neutrophil to lymphocyte,and the infiltration of neutrophils into tumors on the prognosis of lung cancer were reviewed. It is suggested that neutrophils may play an important role in the occurrence, development and prognosis of lung cancer, leading to further understanding of the functions of these important immune cells in tumor microenvironment, which may provide new ideas for the studies on treatment and prognosis of lung cancer.
【CateGory Index】： R734.2