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《Chinese Journal of Antibiotics》 2011-12
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Genetictoxicity of tenofovir dipivoxil fumarate

Feng Xing-lei1,Jin Lei1,Jia Jian-wei1 and Li Mao2(1 Sichuan Industrial Institute of Antibiotics,China National Pharmaceutical Group Corporation,Chengdu 610052; 2 Pharmaceutical Research Institute of Tongwei Co.,Ltd,Chengdu 610211)  
Objective To evaluate the genotoxicity of tenofovir dipivoxil fumarate(TDF) and provide the theory basis for its clinical medication.Methods Salmonella reversion test(Ames test),chromosomal aberration test of CHL cells and mouse marrow micronucleus assay were used to investigate the genotoxicity of TDF.Results Various dosages of TDF showed no mutagenic effects on salmonel latyphimurium in the Ames test,no chromosomal aberration effects were observed after CHL cells exposed to various dosages of TDF with or without rat liver supernatant 9(S9) and TDF did not have inductive effects on formation of polychromatic erythrocyte micronucleus in mouse bone marrow micronucleus test.Conclusion TDF has no genotoxicity based on the Ames test,CHL chromosomal aberration test and micronucleus assay in the experimental conditions.
【Key Words】: Tenofovir dipivoxil fumarate Genotoxicity test Ames test Chromosomal aberration test Micronucleus test
【CateGory Index】: R114
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