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The Improvement of H_2O_2 Induced Osteoblast Damage by Lycopene

HUI Bo-di~1,PEI Ling-peng~2(1.College of Applied Art & Science of Beijing Union University,Beijing 100083,China;2.Center University of Nationalities,Institute of Chinese Minority Traditional Medicine,Beijing 100081,China)  
Objective:To investigate the effect of lycopene on enhancing the function of anti-oxidative damage in osteoblast.Methods:MC3T3-E1 osteoblasts were randomly divided into five groups,including control group,model group,lycopene group[low dose(1×10~(-8) mol/L),middle dose(1×10~(-7) mol/L),high dose(1×10~(-6) mol/L)],whose activity of cells,superoxide dismutase(SOD),the content of reactive oxygen species(ROS),lipid oxygen(LPO) and membrane fluidity were tested and compared.Results: Compared with lycopene groups,the activity of cells,SOD activity and membrane fluidity in the model group were significantly decreased(P0.01).However,the content of ROS and LPO were significantly raised(P0.01).Conclusion: H_2O_2 can cause oxidative damage of MC3T3-E1 osteoblasts,but lycopene can prevent and decrease its influence.
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