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Estimation of genetic inheritance in case-control studies

LI Na;LI Zhengbang;ZHU Jiayan;School of Applied Science,Beijing Information Science and Technology University;School of Mathematics and Statistics,Central China Normal University;School of Information Engineering,Hubei University of Chinese Medicine;  
For selective genetic models,risk alleles were co-dominant coded. Logistic regression was used to select genetic model in case-control study. Numerical simulations show that our new method is more effective than Hardy-Weinberg equilibrium test to choose the genetic model. Applications to six single nucleotide polymorphisms(SNPs) for breast cancer and eight SNPs for Type 2 Diabetes further show the feasibility and effectiveness of our proposed method.
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