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Study of Pharmacokinetics on Matrine

Luo Xueya Xia Bingnan  
The pharmacokinetic study of matrine was carried out by means of color- imetry.Matrine was injected intravenously into rabbits and the curve of blood concentration vs time was described by using an open two-compartment model. The pharmacokinetie parameters wre A,62.57 ug/ml;B,14.22ug/ml;α, 0.5045min~(-1);β,0.00905min~(-1);T_(1/2α),1.37min;T_(1/2β),76.58min;Cl,23.59 ml/min/kg;Vc,0.52L/kg;Vd,2.61L/kg.The content of matrine in rats' each tissue after administered orally was in turn the kidney,liver,lung,brain, heart and blood.Matrine was given orally to rats.The cumulative quantity of excretion of unchange drugs was 53.73% of the total dose in urine in 48h, 0.36% infeces in 24h and 0.27% in bile in 12h,while administered intraveno- usly to rabbits,was 9.39% of the total dose in urine and 0.37% in bile in 12h respectively.
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