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Clinical Observation on Treatment Efficacy of Malignant Pleural Effusion by the use of Integrative OK-432,Cisplatin and Mitomycin

LV Lili,ZHU Shuyang,YANG Rongli,ZHOU Xiaobing(The Affiliated Hospital of Xuzhou Medical College,Xuzhou 221002,China)  
Objective To observe the effects of OK-432 combined with cisplatin(DDP) and mitomycin(MMC) in the treatment of malignant hydrothorax.Methods Forty patients with malignant hydrothorax were randomly divided into the therapeutic group(OK-432+DDP+MMC,20 patients) and the control group(DDP+MMC,20 patients).After completely depleting malignant pleural effusion,the therapeutic group patients were slowly injected with OK-432+ cisplatin + mitomycin into the thoracic cavity and the control group were injected cisplatin+ mitomycin.Results The response rate of the therapeutic group was 90%(18/20) and the control group was 65%(13/20);P0.05.Conclusion The therapeutic effect of OK-432 combining with cisplation and therapy is markedly effective for malignant pleural effusion,and the toxic reaction is lower.It has better clinical value.
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