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The latest progress on the molecular mechanisms of pharmacological activity of saikosaponins

CHENG Yu-peng;MA Ai-ping;CHEN Qi;LIN Jin-hua;LI Tian-cong;LI Hong-kun;School of Pharmacy,Heilongjiang University of Chinese Medicine;School of Life Science and Technology,Harbin Normal University;  
The main bioactive chemical ingredients of traditional Chinese medicine Bupleurum are saikos-aponins, oleanane-type triterpenoid saponins, which are applied in the functions of antipyretic, sepative, analgesic,antibechic. The molecular mechanisms of pharmacological activity of saikosaponins have constantly been revealed.This article reviews recent advances in the effects of saikosaponins on reversing multiple drug resistance(MDR),hepatopretection, anti-inflammatory and anti-tumor. It will provide reference for further application of saikos-aponins in clinical practice.
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