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Clinical Research of Dandelion With Vancomycin Treating Methicillin-resistant Coagulase-negative Staphylococci Infection

ZHOU Wei-ran,LI Bo-wan,CHEN Yue-fu,et al (The Third Affiliated Hospital,University of South China,Hengyang,Hunan 421900,China)  
Objective Compared with vancomycin alone,to evaluate the clinical effect of dandelion with vancomycin treating methicillin-resistant coagulase-negative staphylococci(MRCNS) infection.Methods Using randomized parallel control method,67 patients with MRCNS infection were divided into two groups,treatment group(n=34) with dandelion and vancomycin,and control group(n=33) with vancomycin alone,without other antibiotics.Patients symptoms,the actual days of medication,efficiency and the ratio of bacterial clearance after administration were carefully observed.Results The cure ratio of treatment group was higher than control group(97.1% and 81.8 % in two groups respectively,P0.01).The ratio of effective power in treatment group was higher than control group(100% and 93.9% in two groups respectively,P0.05),The ratio of bacterial clearance in treatment group(97.1%) was also higher than control group(84.8%)(P0.01).The actual days of medication in treatment group was less than control group(10.8 days and 11.9 days in two groups respectively,P0.01).The incidence of adverse reactions in two groups had no significant difference(P0.05).Conclusion The clinical effect of dandelion with vancomycin treating MRCNS infection were significantly superior to vancomycin alone.
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