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Hepatoprotective Activity of Fucoidan from Laminaria japonica against CCl_4 Induced Hepatic Injury in Mice

REN Dan-dan WANG Qiu-kuan ZHANG Tian-cui HE Yun-hai LI Wei(College of Food Engineering,Dalian Fisheries University,Dalian 116023,China)  
Fucoidan was prepared from Laminaria japonica by enzymatic hydrolysis.Mice were pretreated with fucoidan from Laminaria japonica(200,400,800 mg/kg respectively for 7 days).Then liver injury model was established by administration of CCl4 in mice on the 7th day.The positive control was administrated with 200 mg/kg dimethyl diphenyl bicarboxylate.The activities of serum ALT and AST,the content of MDA and the activity of SOD in hepatic tissue were measured.The hepatic histological changes were observed by optical microscope.The results showed that fucoidan from Laminaria japonica had significantly hepatoprotective activity on CCl4 induced liver damage in mice.Mice treated with fucoidan remarkably prevented the elevation of serum AST,ALT and liver lipid peroxides in CCl4 treated mice(P0.01).Histopathological changes induced by CCl4 were also significantly reduced by fucoidan treatment.
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