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Antidepressant Effect of the Essential Oil and the Volatile Organic Compounds in Air from Rosemary and Lemongrass

TONG Shen-shen,YAO Lei (School of Agriculture and Biology,Shanghai Jiaotong University,Shanghai 200240,China)  
In order to promote the using value of the aromatic plant,further explore its function on the nervous system.By using the mouse forced swimming test(FST)and mouse tail suspension test(TST)models of depression to assess the antidepressant effect of the essential oil(EO) and the volatile organic compounds in air(VOCs) from rosemary and lemongrass.All groups of the EO and the VOCs significantly shortened the motionless time and despair time in the two behavioral despair animal models of depression,and the results are significantly different to the control group.But the pharmacology function of the EO and the VOCs are generally weaker than the fluoxetine.The result of TST showed that the best four groups are successively:the fluoxetine,the EO of rosemary at medium dosage, the VOCs of rosemary in low density and the EO of lemongrass at high dosage.And the motionless time are seperately shortened by 56.6%,52.7%,35.9%and 34.1%.The result of FST showed that the best four groups are successively:the EO of rosemary at medium dosage,the fluoxetine,the VOCs of rosemary in low density and the EO of lemongrass at high dosage.And the motionless time are seperately shortened by 40.1%、36.3%、35.3%and 35.1%.We can draw the conclusion that the EO and the VOCs from rosemary and lemongrass presented obviously antidepressant effect in the behavioural despair models of depression.
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