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Research of Ashitaba Chalcone on the Antioxidant Effect in Tumor-Bearing Mice

HOU Fang-lin,ZHONG Jin-yi,ZHANG Yan(Haici Hospital Affiliated to Medical College of Qingdao University,Qingdao Shandong 266033)  
Objective To study the impacts of ashitaba chalcone(AC)on cell antioxidant capacity in H22 hepatoma-bearing mice.Methods 50 H22 hepatoma-bearing mice were randomly divided into five groups:a tumor control group,a cytoxan(CTX)group,an AC high-dose group,an AC middle-dose group and an AC low-dose group,10 rats in each one.In AC low-dose,middle-dose and high-dose groups,AC of 8,16,32 mg/kg was administered by gastric infusion separately everyday.In tumor control group,physical saline was given.In CTX group,CTX was administered with intraperitoneal injection,20mg/kg once every two days.On the 11th day,all the mice were sacrificed and tumor tissue was collected for the determination of serum lipid peroxide(MDA),superoxide(SOD),glutathione peroxidase(GSH-Px),total antioxidant capacity(T-AOC)levels,etc.MTT assay was adopted to determine the proliferation activity of tumor cell in mice of each group.Results Of AC groups,the antioxidant effect of cell in mice were significantly improved in AC middle-dose and AC high-dose groups,indicating significant statistical difference(P0.01).The hepatoma cell proliferation activity was(1.135±0.032)U/mL in tumor control group and was(0.716±0.018)U/mL in AC high-dose group,presenting significant statistical difference in comparison(P0.05).Conclusion Ashitaba chalcone can enhance the antioxidant capacity and inhibit the proliferative activity of tumor cell in H22 hepatoma-bearing mice.
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