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Meta-analysis on relationship between induced abortion and breast cancer

LI Ni-na1,CHEN Lei2,LI Zheng1,et al(1.The Research Institution of Shandong Provincial Behavior Medicine Education,Jining Medical College,Jining,272000,China; 2.Xiangshan County Center for Disease Control and Prevention,Xiangshan,315700,China)  
Objective To assess the association between induced abortion and breast cancer quantitatively.Methods Literatures published in English and Chinese reporting about the case-control study of the relationship between induced abortion and breast cancer from 1991 to 2011 were searched in this study.Revman version 5.0 was used for meta-analysis to calculate the odds ratios(OR) and 95% confidence interval(95% CI).Possible publication bias was tested and a sensitivity test was conducted.Results Seventeen high-quality case-control studies involving 20 421 patients and 34 261 health controls were included.The literatures had significant heterogeneity,so random effect model was used in the study.The overall OR(95% CI) was 1.28(1.06,1.54).Subgroup analysis indicated that there was no significance association of once induced abortion with breast cancer,OR=1.05,95% CI(0.92,1.19),but two and more times of induced abortion was significantly associated with breast cancer,OR=1.34,95% CI(1.03,1.75).Conclusion Induced abortion is a possible risk factor for breast cancer,especially multiple abortion may increase the risk of breast cancer.
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