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Drug Resistance Analysis of 89 Strains of Staphylococcus aureus Isolated from Sputum Specimens of 4 238 Children with Lower Respiratory Tract Infection

LU Xiafei1,LI Jianping2,HUA Chunzhen3,YAN Jie4 (1.Faculty of Laboratory Medicine, Zhejiang Medicine College, Zhejiang Hangzhou 310053,China; 2. the Affiliated Children Hospital of Zhejiang University, Zhejiang Hangzhou 310006, China; 3. Department of Pediatrics, Teacher Training College of Hangzhou, Zhejiang Hangzhou 310012, China; 4. Department of Medical Microbiology and Parasitology, College of Medical Science, Zhejiang University, Zhejiang Hangzhou 310031, China);  
Staphylococcus aureus strains in deep sputum specimens of 4 238 children with lower respiratory tract infection were isolated and cultured. By using bacterium automatic analysis system Vitek 60, identification and drug resistance of the isolates were performed. In the 4 238 specimens, 2.1%(89/4 238)were positive for S.aureus. Of the isolated 89 strains of S.aureus,95.5%(85/89)could produce β-lactamase and 4.5%(4/89)belonged to MRSA.Three of the 4 MRSA strains showed multiple drug resistance. 96.6% and 48.3% of the strains were resistant to penicillin and erythromycin, respectively, while 14.6%~25.9% of the strains were resistant to SMZ co, lincomycin and streptomycin. Resistance rates of the strains to the tested common antibiotics such as gentamycin, oxacillin, ampicillin/sulbactam, amoxicillin/clavulanic acid, cefazole, ciprofloxacin and levofloxacin were lower than 10%. The results of this study indicated that drug resistance of S.aureus strains causing lower respiratory tract infection in children was still sensitive to most of the common antibiotics clinically used, and β-lactamasestrains of S.aureus were high frequently present but the proportion of MRSA in the isolates was low. ;
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