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Effect of Inonotus obliquus polysaccharide on survival and cytokines in sera of mice infected with Toxoplasma gondii

LI Jia-jia1,JU Yu-lin1*,ZHANG Hou-shuang2,YU Long-zheng1,LI Yang3(1.Agricultural College of Yanbian University,Longjing 133400,China; 2.Shanghai Veterinary Research Institute,Chinese Academy of Agricultural Sciences,Shanghai 200241,China; 3.Changchun ProteLight Pharmaceutical & Biotechnology Co.,Ltd,Changchun 130012,China)  
The aim of this study was to investigate the effect of Inonotus obliquus polysaccharide against Toxoplasma gondii and to analyze the cytokine response in murine models of infection with T.gondii RH strain.The mice in the medium-dose group had the highest survival rate and the longest survival time.The analysis for cytokines showed that the levels of IFN-γ in the medium-dose and high-dose groups were significantly higher than those in other groups(P0.001).The IL-2 levels between the high-dose group and other groups were very significantly different(P0.001).It suggested that the medium-dose of Inonotus obliquus polysaccharide had high activity against T.gondii in vivo and might make IFN-γ and IL-2 increase to the appropriate level,thus decreasing the damage of T.gondii infection to mice.
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