Clinical and experimental study on therapeutic effect of compound shenqitang on gastric carcinoma *
SHEN Hong Xun 1, CHEN Li 2, ZHOU Shu Jun 1, CHEN Yu Quan 1, FAN Yong 1 and LU Li Ping 1 1Department of General Surgery, Affiliated Hospital and 2Department of Pathology, Nantong Medical College, Nantong 226001, Jiangsu Province, Ch
AIM To observe the therapeutic effect of compound Shenqitang decoction containing mainly Astragalus membranaceus , ginseng and Panax pseudoginseng on gastric adenocarcinoma after gastrectomy, and to study its inhibitory effect on gastric adenocarcinoma induced by MNNG in Wistar rats. METHODS From Apr 1985 to Dec. 1996, 35 patients with gastric carcinoma, including 25 who received curative gastrectomy and 10 who underwent palliative gastrectomy, were treated with the compound Shenqitang for two courses (three months for a course) in the first and second year after operation, and for one course in the third. Of them, 22 were given chemotherapy with MMC and 5 FU. Twelve of them were treated for 3 courses within 2 years and 10 stopped the medication because of the inhibitory effect of the drugs on bone marrow. In addition, 35 patients of the control group were operated on (31 curative gastrectomy and 4 palliative gastrectomy). Of them, 21 received chemotherapy (9 stopped treatment). Wistar rats ( n =50) were fed with MNNG solution (100mg/L) and with particles of foodstuff containing compound Shenqitang (18mL/kg rat's body weight) for 9 months. Another 50 Wistar rats were fed with MNNG solution and particles of foodstuff only at the same time as controls. RESULTS In Chinese drug group, the 5 , 8 and 10 year survival rates were 80 0%(16/20), 60 0%(9/15) and 57 1%(8/14), respectively, while in the control group they were 58 6%(17/29), 40 0%(4/10) and 14 3%(1/7), with a statistical difference ( P 0 05). In the Chinese drug group, 7 of the 50 rats died naturally, and 43 rats were still living for 9 months. After they were killed, normal gastric mucous membrane was found in 32 rats (74 4%), dysplasia of the mucous membrane in 8(18 6%), and gastric adenocarcinoma in 3 (6 9%). In the control group, 11 of the 50 rats died naturally, and 39 were still living for 9 months. Dysplasia was discovered in 16 (41 1%), and gastric adenocarcinoma in 23 (58 9%). There was a statistically significant difference between the two groups ( P 0 01). CONCLUSION Compound Shenqitang has good therapeutic results in combined operative treatment of gastric carcinoma. It could lower the incidence of gastric adenocarcinoma induced by MNNG in rats.