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Experimental Study on Anti-inflammatory and Analgesic Effects of Different Extracts from Chinese Lobelia

HUANG Li-de1,GUO Li-qiang2,PAN Ting-qi1,PAN Xi-ying1,YAN Zu-di1,LIU Sheng-li1,ZHAO Shan-min3,HE Xian-jiao3(1.School of Clinical Medicine;2.School of Clinical Laboratory Medicine;3.School of Basic Medicine,Youjiang Medical University for Nationalities,Baise 533000,China)  
Objective To study analgesic and anti-inflammatory effects of different extracts from Chinese lobelia.Methods Water extract and 75% alcohol extract were obtained from Chinese lobelia.Anti-inflammatory effect of Chinese lobelia was studied by using mouse abdominal cavity capillary permeability increase test induced by acetic acid,mouse auricle swelling test induced by xylene,mouse toe swelling test induced by 10% albumen test in mice.Analgesic action of Chinese lobelia was studied by mouse aceticacid-induced twisting test and hot plate test.Results In the same dose,the water extract of Chinese lobelia significantly inhibited the twisting effect induced by acetic acid in the mice(P0.01).The extracts of Chinese lobelia increased the threshold of pain in the mice significantly by hot plate test,after the treatment for 1 h or 2 h(P0.05,P0.01).The extracts of Chinese lobelia inhibited xylene-induced mouse auricle swelling(P0.05).The extracts of Chinese lobelia also significantly inhibited 10% albumen-induced mouse toe swelling,0.5 h,1 h,2 h or 4 h after the induced inflammation(P0.05,P0.01).Conclusion Chinese lobelia has obvious analgesic and anti-inflammatory effects.
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