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Pathogenesis of osteomalacic skeletal fluorosis an experimental study

Sun Mei,et al.Institute of Endemic Diseases,Norman Bethune University of Medical Sciences.Changchun  
Experimental osteomalacic skeletal fluo-rosis was produced in rats kept on amonotonous diet of low calcium (Ca) anddirnking water supplemented with excess fluo-ride.The following biochemical and metabolicchanges were found:(1)the serum content ofCa was markedly lowered with no significanfchangein the contents of magnesium and phos-phorus;(2)the serum content of 1,25-(OH)_2D_3 was elevated with an inverse correla-tion to the serum Ca level;(3)the number ofosteoclasts increase,indicating a secondary hy-perparathyroidism in response to the hypocal-cemia;(4)The urine content of hydroxyprolinerose with a direct correlation to the number ofosteoclasts,indicating an increase of bone re-sorption and collagen disintegration;(5)theserum alkaline phosphatase activity was ele-vated correlated inversely with the serum Cacontent,indicating an increased activity of os-teoblastic function.The above mentionedchanges appeared in slight degrees in thegroup fed with monotonous diet only,but wereexacerbated by the administration of excessfluoride.The pathogenesis of osteomalacicskeletal fluoride.The pathogenesis of osteo-malacic skeletal fluorosis is discussed.It isconsidered that low dietary Ca intake is an es-sential factor in the development of osteoma-lacic skeletal fluorosis,that the changes of cal-ciotropic hormones secondary to the hypocal-cemia aggravate the severity of osteomalacia,and that improvement of Ca nutrition state ofthe inhabitants can play an important role inthe control of endemic fluorosis.
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