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Anticancer activity of phycocyanin

WANG Yong +1, QIAN Feng +1, QIAN Kai-xian +1, DONG Qiang +2 ;(1.Dept. of Bioscience and Technology, Zhejiang Uni., Hangzhou 310027, China 2.Medical Academg of Shandong Province. Jinan 250062, China)  
Cell growth can be quantitatively shown by the MTT method; Flow cytometry technique (FCM) was applied to test the phase of the cell division cycle by its content of DNA. The authors' use of tow methods for researching the inhibition activity of phycocyanin on cancer cells indicated that phycocyanins had obvious inhibition effect on HeLa cells in vitro. The inhibition rate on cancer cells was 3.5% to 31.0% when phycocyanin supplementation ranged from 10 {mg/L } to 80 mg/L. The preliminary conelnsion on the mechanism of inhibition activity is phycocyanin transformation of the HeLa cells from the synthetic phase(S)?G -2 or divided phase (M) to G -1 phase where they are accumulated, because the DNA synthesis of cancer cells was decreased by the action of phycocyanin.
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