Full-Text Search:
Home|About CNKI|User Service|中文
Add to Favorite Get Latest Update

Effects of the standardized purified dry extract Polinacea~(TM) from Echinacea angustifolia on immunity function of peripheral blood mononuclear cells of dairy heifers

WU Hua1,Alessandro Nardone2,Nicola Lacetera2 (1.College of Agriculture and Animal Husbandry,Qinghai University,Xining 810003,China; 2.Tusica University,Viterbo 01100,Italy)  
PBMC from six Holstein heifers were incubated with 0,6.3,20,60,or 180μg/mL of the experimental compound PolinaceaTM from Echinacea angustifolia with or without concanavalin A(Con A,1μg/mL)or pokeweed mitogen(PWM,0.6μg/mL),respectively.Proliferation of PBMC was assessed by ELISA,and secretion of IFN-γ was stimulated by ConA(2.27μg/mL).In result,the lowest and highest increase of proliferation were observed with PolinaceaTM at 6.3(2-fold increase) or 180(10-fold increase)μg/mL,respectively.PolinaceaTM at 180μg/mL reduced ConA-driven proliferation,whereas at 20 and 60μg/mL improved proliferation of PWM-stimulated PBMC.However IFN-γ secretion was not affected by PolinaceaTM.In conclusion,PolinaceaTM could modulate proliferation of bovine PBMC,and deserve to be tested in vivo to define conditions that might benefit from its utilization.
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©CNKI All Rights Reserved