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Bone mineral density of forearm of female residents in endemic fl uorosis area

ZHAN Zhongchun,LIU Jianjun,XU Honglan Hunan Provincial In stitute for Occupational Hygiene and Control of Occupational Diseases,Changsha 4 10007,China  
Objective To determine the effect of high leve l fluoride in drinking water on bone mineral density (BMD), thereby finding a meth od for screening endemic fluorosis Methods 80 female resident s in the endemic fluorosis area and 71 women in urban area were recruited randoml y as subjects and controls,respectively Fluoride concentration in urine was det er mined,and single photon absorptionetry (SPA) was used to determine the BMD of th e forearms The difference in BMD and detection rate of osteoporosis between the two groups was analyzed Results Compared with the controls, th e difference in the mean value of BMD was inconsistent in different age groups,wi thout regularity,however,the rate of osteoporosis been detected is higher in th e subjects of endemic fluorosis area than the controls (P0 001) C onclusion High concentration of fluoride in the drinking water may resu lt in the variation of BMD in the forearm by population levels The rate of oste o porosis been detected in the female group is higher in the endemic fluorosis are a than the normal population,osteoporosis and osteosclerosis in the endemic fluo rosis area may be regarded as a screening method
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