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Genotype analysis of enteroviruses causing hand, foot and mouth disease in Shaoxing City

JIANG Zhuojing;GE Xiaoping;CHEN Jinkun;WANG Jiling;Microbiological Laboratory, Shaoxing Center for Disease Control and Prevention;Xiaoshan Center for Disease Control and Prevention;  
Objective To investigate the genotypes of enteroviruses causing hand,foot and mouth disease(HFMD) in Shaoxing City,so as to provide insights into HFMD control.Methods The anal and pharyngeal swab specimens were collected from HFMD cases under 14 years of age reported by sentinel hospitals of HFMD in Shaoxing City from 2018 to 2020.The enterovirus genotypes were determined by quantitative real-time PC.R(qPCR) assay and sequenced by BLAST,and the constitution and temporal distribution of enterovirus genotypes were descriptively analyzed.Results A total of 1 267 anal and pharyngeal swab specimens were collected from children with HFMD,and 661 specimens were positive for enteroviruses,with a positive rate of 52.17%.Among the 661 enterovirus-positive specimens,70 specimens were tested positive for EV71(5.52%),208 specimens tested positive for Cox、16(16.42%),239 specimens tested positive for CoxA6(18.86%);23 specimens tested positive for CoxA10(1.82%),and 121 specimens tested positive for other 10 genotypes,including CoxA2,CoxA4,and CoxA5.The prevalence rates of EV71 were 14.08%,0.72% and 1.84%from 2018 to 2020,and the detection of EV71 peaked during the period between April and July,2018.The prevalence rates of CoxA16 were 10.98%,26.57% and 11.98 from 2018 to 2020,and the detection of CoxA16 peaked during the period between April and August,and between November and December,2019.The prevalence rates of CoxA6 were10.50%,14.73% and 30.88% from 2018 to 2020,and the detection of CoxA6 peaked during the period between May and December,2020.Conclusions EV71,CoxA16 and CoxA6 were predominant enterovirus genotypes causing HFMD in Shaoxing City from 2018 to 2020,and the detection of CoxA6 appeared a tendency towards a rise.
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